"In the 1920s, long before the appearance of modern antidepressants, physicians tried to treat listless men with a serum of ground-up animal testes, which they imagined contained the essence of male virility. In the '40s and '50s, when that essence had been discovered and synthesized in a laboratory, injections of testosterone were prescribed for depression."
http://www.bodybuildingpro.com/testosteronetested.html
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